Proactiv MD At the point when I gave leaving a shot the toner, I saw my skin was much drier. I stuck it out however in view of an easily overlooked detail called retinization. Retinization is the alteration time frame that your skin needs to become acclimated to the retinoid. Your skin may begin to look red and flaky initially however ought to die down around week 4. This is the reason Proactiv strongly prescribes utilizing a lotion to help calm a portion of the side effects while they’re irksome to you.