Body Ally Keto You should also consider a change in diet and some exercise to lose weight. The Mayo Clinic did come to a conclusion for off the shelf weight loss pills, which basically said: “The reality is there is no magic bullet to help lose weight. The best way to lose weight effectively and keep it off would be by lifestyle changes like watching your portion sizes, being physically active, eating healthy, and consuming low-calorie foods. It may not be magic, but it does work.”